Malvern Panalytical – Your partner in development of successful pharmaceutical products

Malvern Panalytical is a leading technology and solution provider for the pharmaceutical industry, with knowledge and expertise to support the manufacture and development of safe and effective pharmaceuticals. 

The company is the culmination of a merger between two leading analytical technology companies. The first company, Malvern Instruments, is a global leader in particle sizing, particle shape, chemical identification and process control technologies. Merging with PANalytical Instruments, a company specializing in X-ray technologies to examine crystal structure, elemental composition and purity of pharmaceutical products and ensure the quality and composition of products, the new Malvern Panalytical was forged. 

Malvern Panalytical solutions add value throughout the pharmaceutical development cycle, from discovery and preformulation through to scale-up and manufacturing. Our products help gain understanding of critical material attributes (CMAs) and critical process parameters (CPPs) associated with defining, optimizing and controlling drug product performance. From measuring the activity, molecular confirmation or stability of an API, through to understanding the morphological properties, processability and quality of excipients, Malvern Panalytical technologies can generate better understanding of how material properties impact pharmaceutical products.

Malvern Panalytical’s strength goes beyond our breadth of complementary physiochemical characterization tools. Through decades of experience in the pharmaceutical industry our company has developed an in-depth understanding of the requirements of working in a highly regulated environment. We ensure that our customers are supported through the entire product lifecycle, effectively applying our solutions to accelerate product development and optimize product quality.

The discovery phase in drug development is primarily focused on target molecule identification and validation, colloquially separating the wheat from the chaff. Malvern Panalytical’s range of screening tools enable a detailed understanding of the binding and crystallographic properties of a candidate molecule. The knowledge gained from these technologies eliminates false positives often found in alternative techniques and provides a measure of structural purity, ensuring that the candidates moved into the next phase of development meet the high standards required. This enables scientists to make better decisions at every step, resulting in a more cost-effective, efficient and predictive molecule discovery process.

Providing the best drug candidate with optimal solid-state characteristics is a key step in pharmaceutical development. Our goal is to provide customers with the best solutions to optimize their crystallization processes and elucidate the appropriate polymorphic form with the right physical characteristics.

Malvern Panalytical provides the capability to measure critical-to-quality attributes such as crystal habit, particle size, particle shape, polymorphic form and sample purity. Our state-of-the-art characterization solutions help our clients quickly characterize these key properties, avoiding problems downstream with the bioavailability, stability and processability of the drug substance.

Formulation Development is a multi-faceted discipline that needs to measure, refine and optimize the properties of the drug substance, excipients and delivery vehicle to generate a stable, reliable and safe drug product. Malvern Panalytical’s range of complimentary and orthogonal technologies and solutions ensure product quality and consistency standards are exceeded and regulatory requirements are met. 
Our technologies and solutions can be applied to a range of drug products including: 

• Orally inhaled and nasal drug products (OINDPs) - nasal sprays, dry powder inhalers, metered dose inhalers, nebulizers
• Oral solid dosage formulations - capsules, tablets for immediate release or extended release
• Topical semi-solid formulations - creams, gels
• Sterile liquid dosage formulations - ophthalmic, oral
• Injectables - intravenous, intramuscular, subcutaneous injectables
• Liposomes for drug delivery
• Semi-solid formulations for oral administration - syrups, suspensions

Malvern Panalytical’s unique advantage comes from our expertise in the interoperability of the complementary methods available for particle size, particle shape, surface charge, rheological and chemical identification measurements.

Using the Malvern Panalytical formulation development toolset helps you assess the bioavailability, processability, stability and content uniformity of your chosen lead candidate formulation.

The discovery phase in drug development is primarily focused on target molecule identification and validation, colloquially separating the wheat from the chaff. Malvern Panalytical’s range of screening tools enable a detailed understanding of the binding and crystallographic properties of a candidate molecule. The knowledge gained from these technologies eliminates false positives often found in alternative techniques and provides a measure of structural purity, ensuring that the candidates moved into the next phase of development meet the high standards required. This enables scientists to make better decisions at every step, resulting in a more cost-effective, efficient and predictive molecule discovery process.