With more than 135 years of experience, Dr. Paul Lohmann^® is the expert in the manufacture of Mineral Salts for the pharmaceutical industry, specializing in the manufacture of Salts for the biotechnological manufacturing processes and the manufacture of special quality Salts for parenteral dosage forms. Our German production facilities are GMP certified and our product portfolio includes more than 400 different Salts. Some of these Salts fulfill specific functions in bioproduction processes and are used in a variety of ways, e.g. as nutrients in fermentation and as process aids in yield and harvest. In the final formulation of vaccines or monoclonal antibodies, Salts such as Phosphates, Citrates and Sulfates are used for technological reasons in order to stabilize the biologically active substance and make it applicable.

Dr. Paul Lohmann^® can modify chemical and physical parameters according to customers’ requirements. Since multiple repacking bares the risk of contamination, Dr. Paul Lohmann^® offers individual packaging and a high level of transparency along the entire supply chain.

Dr. Paul Lohmann GmbH & Co. KGaA

Hauptstrasse 2

31860 Emmerthal/Germany

T +49 5155 63-0

sales@lohmann4minerals.com

www.lohmann4minerals.com

Amino Acids are very often used as nutrients in cell culture media and are therefore an indispensable part of many upstream processes. However, many Amino Acids are poorly or not soluble in an aqueous medium, which can lead to losses in yield and poor quality of the finished products.

To counteract these solubility problems, Paul Lohmann® developed Tyrosine and Aspartic Acid Salts with improved solubility profiles and increased dissolution rates.

• L-Tyrosine Disodium Salt
• L-Aspartic Acid Sodium Salt

Please contact us, if you are looking for further Salts of Amino Acids.

Dipotassium Hydrogen Phosphate 3-hydrate, Ammonium Sulfate, Sodium Sulfate 10-hydrate and Magnesium Acetate are widely used in biopharmaceutical and diagnostic applications. It is known that these products have a high tendency to lump due to their high hygroscopicity, which hinders and complicates the entire production process. That is why Dr. Paul Lohmann^® developed free-flowing qualities that ultimately reduce the manufacturer‘s time and costs.

• Ammonium Sulfate
• Magnesium Acetate
• Dipotassium Hydrogen Phosphate 3-hydrate
• Sodium Sulfate 10-hydrate

Endotoxins can cause undesirable effects on cell proliferation or cell function. Low in Endotoxin qualities enable the development of high sensitive cell lines in an optimal and controlled environment.

Sodium Succinate 6-hydrate is used as buffer in cell culture media and as excipient. Dr. Paul Lohmann^® has invested into a state-of-the-art dedicated GMP plant for Low in Endotoxin Salts. With our unique Quality by Design approach, we have developed Sodium Succinate 6-hydrate Low in Endotoxins. The advantage for the customer lies in the seamless integration and reduced risks and costs in production.

In addition to Sodium Succinate 6-hydrate, Dr. Paul Lohmann^® offers a wide range of Low in Endotoxin Salts such as Acetates, Sulfates, Citrates and Phosphates.

Acetates

• Calcium Acetate
• Magnesium Acetate 4-hydrate
• Potassium Acetate
• Sodium Acetate 3-hydrate
• Zinc Acetate 2-hydrate

Aspartates

• Magnesium DL-Aspartate 4-hydrate
• Potassium DL-Aspartate 0.5-hydrate

Citrates

• Citric Acid, anhydrous
• Monosodium Citrate, anhydrous
• Trisodium Citrate, anhydrous
• Trisodium Citrate 2-hydrate

EDTA

• Calcium Disodium EDTA

Glycerophosphates

• Sodium Glycerophosphate

Gluconates

• Calcium Gluconate 1-hydrate
• Magnesium Gluconate

Lactates

• Sodium Lactate Solution; approx. 52%
• Sodium Lactate Solution; approx. 60%

Phosphates

• Potassium Dihydrogen Phosphate
• Dipotassium Phosphate
• Monosodium Phosphate, anhydrous
• Monosodium Phosphate 2-hydrate
• Disodium Phosphate 12-hydrate

Succinates

• Sodium Succinate 6-hydrate
• Disodium Succinate, anhydrous

Sulfates

• Magnesium Sulfate 7-hydrate

Sodium Sulfate, anhydrous

Dr. Paul Lohmann^® manufactures a broad portfolio of high-quality Phosphates adaptable to your specific needs. Phosphates are required in all biopharmaceutical production streams. While our Phosphates meet the requirements of common pharmacopoeias, we also offer individual analytical profiles. These as well as Phosphate blends and a variety of individual packaging make Dr. Paul Lohmann^® your solution-oriented supplier.

Potassium

• Monopotassium Phosphate
• Dipotassium Hydrogen Phosphate
• Dipotassium Hydrogen Phosphate 3-hydrate

Sodium

• Monosodium Phosphate, anhydrous
• Monosodium Phosphate 1-hydrate
• Monosodium Phosphate 2-hydrate
• Disodium Hydrogen Phosphate, anhydrous
• Disodium Hydrogen Phosphate 7-hydrate
• Disodium Phosphate 2-hydrate
• Disodium Phosphate 12-hydrate
• Trisodium Phosphate 12-hydrate